Name | Almokalant |
Synonyms | Almokalant Benzonitrile, 4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]- |
CAS | 123955-10-2 |
Molecular Formula | C18H28N2O3S |
Molar Mass | 352.496 |
In vitro study | Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K + current. |
In vivo study | Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats. |
biological activity | Almokalant is a third class of antiarrhythmic drugs, potassium channel blockers, the unique component Ikr that inhibits the time-dependent delayed rectifier potassium ion current. |
Target | wavelength channel |